Characteristics of Neuropsychiatric Presentations of CJD and Other Prion Lead Investigator: Brian Appleby Institution : Johns Hopkins E-Mail : applebyb77@yahoo.com Proposal ID : 44 Proposal Description: To examine clinical, diagnostic, and pathological characteristics of such sx's. [Note: CJD is not a variable in the UDS] Specific Aim #1: To establish the existence of neuropsychiatric phenotypes of CJD Specific Aim #2: To establish clinical and diagnostic characteristics of neuropsychiatric phenotypes of CJD Specific Aim #3: To examine neuropathological features associated with neuropsychiatric phenotypes of CJD